PERSISTENT OXIDATIVE STRESS IN CANCER

被引：995

作者：

TOYOKUNI, S ^{[1
]}

OKAMOTO, K ^{[1
]}

YODOI, J ^{[1
]}

HIAI, H ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT BIOL RESPONSES,SAKYO KU,KYOTO 606,JAPAN

来源：

FEBS LETTERS | 1995年 / 358卷 / 01期

关键词：

REACTIVE OXYGEN SPECIES; OXIDATIVE DNA DAMAGE; TUMOR BIOLOGY; MUTATION; TRANSCRIPTION FACTOR;

D O I：

10.1016/0014-5793(94)01368-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent nornal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.

引用

页码：1 / 3

页数：3

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