PERSISTENT OXIDATIVE STRESS IN CANCER

被引：995

作者：

TOYOKUNI, S ^{[1
]}

OKAMOTO, K ^{[1
]}

YODOI, J ^{[1
]}

HIAI, H ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT BIOL RESPONSES,SAKYO KU,KYOTO 606,JAPAN

来源：

FEBS LETTERS | 1995年 / 358卷 / 01期

关键词：

REACTIVE OXYGEN SPECIES; OXIDATIVE DNA DAMAGE; TUMOR BIOLOGY; MUTATION; TRANSCRIPTION FACTOR;

D O I：

10.1016/0014-5793(94)01368-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent nornal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.

引用

页码：1 / 3

页数：3

共 37 条

[11] HYDROXYLATION OF DEOXYGUANOSINE AT THE C-8 POSITION BY ASCORBIC-ACID AND OTHER REDUCING AGENTS [J].

KASAI, H ;

NISHIMURA, S .

NUCLEIC ACIDS RESEARCH, 1984, 12 (04) :2137-2145

[12] PHOTOSENSITIZED FORMATION OF 7,8-DIHYDRO-8-OXO-2'-DEOXYGUANOSINE (8-HYDROXY-2'-DEOXYGUANOSINE) IN DNA BY RIBOFLAVIN - A NONSINGLET OXYGEN MEDIATED REACTION [J].

KASAI, H ;

YAMAIZUMI, Z ;

BERGER, M ;

CADET, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (24) :9692-9694

[13] MISREADING OF DNA TEMPLATES CONTAINING 8-HYDROXYDEOXYGUANOSINE AT THE MODIFIED BASE AND AT ADJACENT RESIDUES [J].

KUCHINO, Y ;

MORI, F ;

KASAI, H ;

INOUE, H ;

IWAI, S ;

MIURA, K ;

OHTSUKA, E ;

NISHIMURA, S .

NATURE, 1987, 327 (6117) :77-79

[14]

MALINS DC, 1991, CANCER RES, V51, P5430

[15] THIOREDOXIN REGULATES THE DNA-BINDING ACTIVITY OF NF-CHI-B BY REDUCTION OF A DISULFIDE BOND INVOLVING CYSTEINE 62 [J].

MATTHEWS, JR ;

WAKASUGI, N ;

VIRELIZIER, JL ;

YODOI, J ;

HAY, RT .

NUCLEIC ACIDS RESEARCH, 1992, 20 (15) :3821-3830

[16] REACTIVE OXYGEN-REDUCING AND PROTEIN-REFOLDING ACTIVITIES OF ADULT T-CELL LEUKEMIA-DERIVED FACTOR HUMAN THIOREDOXIN [J].

MITSUI, A ;

HIRAKAWA, T ;

YODOI, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (03) :1220-1226

[17]

NAKAGAWA K, 1990, J BIOL CHEM, V265, P4296

[18]

NAKAMURA H, 1992, CANCER-AM CANCER SOC, V69, P2091, DOI 10.1002/1097-0142(19920415)69:8<2091::AID-CNCR2820690814>3.0.CO

[19]

2-X

[20] TRANSCRIPTIONAL ACTIVATION OF EARLY-RESPONSE GENES BY HYDROGEN-PEROXIDE IN A MOUSE OSTEOBLASTIC CELL-LINE [J].

NOSE, K ;

SHIBANUMA, M ;

KIKUCHI, K ;

KAGEYAMA, H ;

SAKIYAMA, S ;

KUROKI, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 201 (01) :99-106

← 1 2 3 4 →