THE NA+/H+ ANTIPORTER IN ONCOLOGY IN THE LIGHT OF THE SPONTANEOUS REGRESSION OF CANCER AND CELL-METABOLISM

被引：23

作者：

HARGUINDEY, S ^{[1
]}

CRAGOE, EJ ^{[1
]}

机构：

[1] CLIN ESPERANZA, C ESPERANZA 2, E-01002 VITORIA, SPAIN

来源：

MEDICAL HYPOTHESES | 1992年 / 39卷 / 03期

关键词：

D O I：

10.1016/0306-9877(92)90114-R

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multiple metabolic and biochemical interrelationships, as well as the most recent views on mechanisms of malignant cell growth, proliferation, and oncogen activity mediated by the Na+/H+ antiporter, can be integrated from the unitarian point of view of the dynamics of the hydrogen ion to parallel pH-related mechanisms involved in the Spontaneous Regression (SR) of some malignant tumors. Also, pH-related growth inhibitors of the amiloride series are considered as possible agents to be used in the adjuvant and co-adjuvant treatment of some human tumors as well as in the control of the metastatic process and in overcoming cancer multidrug resistance (MDR).

引用

页码：229 / 237

页数：9

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