THE SITE OF ANTIVIRAL ACTION OF 3-NITROSOBENZAMIDE ON THE INFECTIVITY PROCESS OF HUMAN-IMMUNODEFICIENCY-VIRUS IN HUMAN-LYMPHOCYTES

被引：79

作者：

RICE, WG

SCHAEFFER, CA

GRAHAM, L

BU, M

MCDOUGAL, JS

ORLOFF, SL

VILLINGER, F

YOUNG, M

OROSZLAN, S

FESEN, MR

POMMIER, Y

MENDELEYEV, J

KUN, E

机构：

[1] SAN FRANCISCO STATE UNIV,ROMBERG TIBURON CTR,ENVIRONM TOXICOL & CHEM LAB,TIBURON,CA 94920

[2] CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV HIV AIDS,IMMUNOL BRANCH,ATLANTA,GA 30333

[3] EMORY UNIV,SCH MED,DEPT PATHOL & LAB MED,ATLANTA,GA 30322

[4] NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,ADV BIOSCI LABS,FREDERICK,MD 21702

[5] NCI,MOLEC PHARMACOL LAB,BETHESDA,MD 20892

[6] SAN FRANCISCO STATE UNIV,OCTAMER RES FDN,TIBURON,CA 94920

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 20期

关键词：

ZINC FINGER; PROVIRAL DNA BLOCK;

D O I：

10.1073/pnas.90.20.9721

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The C-nitroso compound 3-nitrosobenzamide, which has been shown to remove zinc from the retroviral-type zinc finger of p7NC nucleocapsid proteins, inhibits acute infection of human immunodeficiency virus type 1 in cultured human lymphocytes. The attachment of the virus to lymphocytes and the activities of critical viral enzymes, such as reverse transcriptase, protease, and integrase, are not affected by 3-nitrosobenzamide. However, the process of reverse transcription to form proviral DNA is effectively abolished by the drug, identifying the mode of action of 3-nitrosobenzamide as interrupting the role of p7NC in accurate proviral DNA synthesis during the infectious phase of the virus life cycle.

引用

页码：9721 / 9724

页数：4

共 38 条

[1] POTENTIAL METAL-BINDING DOMAINS IN NUCLEIC-ACID BINDING-PROTEINS [J].