EFFECTS OF LIPOPOLYSACCHARIDE ON HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN-VITRO

被引：5

作者：

BRUNETTI, L

PREZIOSI, P

RAGAZZONI, E

VACCA, M

机构：

[1] UNIV G DANNUNZIO,FAC FARM,CATTEDRA FARMACOL & FARMACOGNOSIA,I-66100 CHIETI,ITALY

[2] UNIV G DANNUNIZO,DEPT PHARMACOL,I-66100 CHIETI,ITALY

[3] CATHOLIC UNIV ROME,DEPT PHARMACOL,I-00168 ROME,ITALY

来源：

LIFE SCIENCES | 1994年 / 54卷 / 10期

关键词：

D O I：

10.1016/0024-3205(94)00554-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The possible involvement of lipopolysaccharide (LPS) and interleukin-1 beta (IL-1 beta) and their eventual interplay in CRH and ACTH release from cultured hypothalamic and pituitary cells respectively, have been studied. IL-1 beta was able to activate the hypothalamo-pituitary-adrenal axis at both hypothalamic and pituitary sites; LPS showed no direct action at hypothalamic level but it was able to inhibit basal and IL-1 beta-induced ACTH release: this could be responsible for a blunting of the adrenal cortex response that normally occurs in septic shock syndrome.

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收藏

页码：PL165 / PL171

页数：7

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