ISOLATION AND IDENTIFICATION OF A CYTOTOXIC PRINCIPLE FROM CHRYSOSPLENIUM-GRAYANUM MAXIM (SAXIFRAGACEAE) AND ITS ANTITUMOR ACTIVITIES

被引：14

作者：

ARISAWA, M

BAI, H

SHIMIZU, S

KOSHIMURA, S

TANAKA, M

SASAKI, T

MORITA, N

机构：

[1] KANAZAWA MED UNIV, DEPT SEROL, KAHOKU, ISHIKAWA 92002, JAPAN

[2] KANAZAWA UNIV, CANC RES INST, DEPT EXPTL THERAPEUT, KANAZAWA, ISHIKAWA 920, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 12期

关键词：

BETA-PELTOBOYKINOLIC ACID; HYDROXYOLEANEN-27-OIC ACID; CHRYSOSPLENIUM-GRAYANUM; CYTOTOXICITY; ANTITUMOR EFFECT; B16-BL6 MOUSE MELANOMA; METH-A MOUSE FIBROSARCOMA; COMBINATION THERAPY;

D O I：

10.1248/cpb.40.3274

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A cytotoxic principle was newly isolated from Chrysosplenium grayanum MAXIM. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth . A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.

引用

页码：3274 / 3276

页数：3

共 11 条

[1] ISOLATION AND CYTOTOXICITY OF 2 NEW FLAVONOIDS FROM CHRYSOSPLENIUM-GRAYANUM AND RELATED FLAVONOLS [J].