共 11 条
[11]
1990, 37TH ANN M JAP SOC P
ISOLATION AND IDENTIFICATION OF A CYTOTOXIC PRINCIPLE FROM CHRYSOSPLENIUM-GRAYANUM MAXIM (SAXIFRAGACEAE) AND ITS ANTITUMOR ACTIVITIES
被引：14
作者：
ARISAWA, M
BAI, H
SHIMIZU, S
KOSHIMURA, S
TANAKA, M
SASAKI, T
MORITA, N
机构：
[1] KANAZAWA MED UNIV, DEPT SEROL, KAHOKU, ISHIKAWA 92002, JAPAN
[2] KANAZAWA UNIV, CANC RES INST, DEPT EXPTL THERAPEUT, KANAZAWA, ISHIKAWA 920, JAPAN
关键词：
BETA-PELTOBOYKINOLIC ACID;
HYDROXYOLEANEN-27-OIC ACID;
CHRYSOSPLENIUM-GRAYANUM;
CYTOTOXICITY;
ANTITUMOR EFFECT;
B16-BL6 MOUSE MELANOMA;
METH-A MOUSE FIBROSARCOMA;
COMBINATION THERAPY;
D O I：
10.1248/cpb.40.3274
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A cytotoxic principle was newly isolated from Chrysosplenium grayanum MAXIM. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth . A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.
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页码：3274 / 3276
页数：3
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