SYNTHETIC APPLICATIONS OF 2-(1,3-DITHIAN-2-YL)INDOLES .4. NEW SYNTHESIS OF THE TETRACYCLIC ABED RING-SYSTEM OF STRYCHNOS ALKALOIDS

被引：23

作者：

DIEZ, A

CASTELLS, J

FORNS, P

RUBIRALTA, M

GRIERSON, DS

HUSSON, HP

SOLANS, X

FONTBARDIA, M

机构：

[1] UNIV BARCELONA,FAC FARM,ORGAN CHEM LAB,E-08028 BARCELONA,SPAIN

[2] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[3] UNIV BARCELONA,DEPT CRISTAL LOGRAFIA MINERAL DIPOSITS MINERALS,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON | 1994年 / 50卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(01)89689-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and versatile synthesis of tetracyclic compounds 10, 22 and 24 presenting the ABED ring system of Strychnos alkaloids is described by closure of the C-1-C-11b bond in the key step. The intermediate tetrahydropyridinium salts 2 have been obtained from 2-(1,3-dithian-2-yl)indole (3) and either 2-cyano-3-ethyl-1-methyl-1,2,3,6-tetrahydropyridine (4a) or N-substituted Delta(3)-piperidein-2-ones (5).

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页码：6585 / 6602

页数：18

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