ANABOLIC ACTIONS OF A MIXED BETA-ADRENERGIC AGONIST ON NITROGEN-RETENTION AND PROTEIN-TURNOVER

被引:15
作者
MARTINEZ, JA
PORTILLO, MP
LARRALDE, J
机构
[1] Department of Physiology and, Nutrition, University of Navarra
关键词
METAPROTERENOL (ORCIPRENALINE); NITROGEN BALANCE; PROTEIN SYNTHESIS; PROTEIN BREAKDOWN;
D O I
10.1055/s-2007-1003762
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Subcutaneous administration of a mixed beta-agonist induced increases in muscle (+13%) and heart (+17%) weights, which were accompanied by a reduction in back (-13%) and perirenal (-27%) fat stores in young male rats, while no changes in liver were observed. The values of nitrogen retention (mg/day) were significantly higher in the beta-agonist treated animals (+16%) as well as those of muscle DNA content (+8%). On the other hand, no statistically significant changes in muscle protein synthetic activity (g protein synthetized/g RNA) were detected (control: 13.4 vs treated: 14.6), while muscle proteolytic activity was decreased (-9%) in those rats administered with the repartitioning agent. In this context, it is suggested that the anabolic effect of metaproterenol should be attributed to a reduction in muscle protein degradation rather than to changes in protein synthesis.
引用
收藏
页码:590 / 593
页数:4
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