IN-VITRO IN-VIVO MODELS FOR PEPTIDE ORAL ABSORPTION - COMPARISON OF CACO-2 CELL-PERMEABILITY WITH RAT INTESTINAL-ABSORPTION OF RENIN INHIBITORY PEPTIDES

被引：44

作者：

CONRADI, RA ^{[1
]}

WILKINSON, KF ^{[1
]}

RUSH, BD ^{[1
]}

HILGERS, AR ^{[1
]}

RUWART, MJ ^{[1
]}

BURTON, PS ^{[1
]}

机构：

[1] UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001

来源：

PHARMACEUTICAL RESEARCH | 1993年 / 10卷 / 12期

关键词：

PEPTIDE; ORAL ABSORPTION; IN-VITRO IN-VIVO CORRELATION; CELL MONOLAYER; CACO-2;

D O I：

10.1023/A:1018990602102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1790 / 1792

页数：3

共 13 条

[1] CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS
ARTURSSON, P
KARLSSON, J
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) : 880 - 885
[2] EPITHELIAL TRANSPORT OF DRUGS IN CELL-CULTURE .1. A MODEL FOR STUDYING THE PASSIVE DIFFUSION OF DRUGS OVER INTESTINAL ABSORPTIVE (CACO-2) CELLS
ARTURSSON, P
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (06) : 476 - 482
[3] THE INFLUENCE OF PEPTIDE STRUCTURE ON TRANSPORT ACROSS CACO-2 CELLS
CONRADI, RA
HILGERS, AR
HO, NFH
BURTON, PS
[J]. PHARMACEUTICAL RESEARCH, 1991, 8 (12) : 1453 - 1460
[4] THE INFLUENCE OF PEPTIDE STRUCTURE ON TRANSPORT ACROSS CACO-2 CELLS .2. PEPTIDE-BOND MODIFICATION WHICH RESULTS IN IMPROVED PERMEABILITY
CONRADI, RA
HILGERS, AR
HO, NFH
BURTON, PS
[J]. PHARMACEUTICAL RESEARCH, 1992, 9 (03) : 435 - 439
[5] HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736
[6] CACO-2 CELL MONOLAYERS AS A MODEL FOR DRUG TRANSPORT ACROSS THE INTESTINAL-MUCOSA
HILGERS, AR
CONRADI, RA
BURTON, PS
[J]. PHARMACEUTICAL RESEARCH, 1990, 7 (09) : 902 - 910
[7] DESOLVATION ENERGY - A MAJOR DETERMINANT OF ABSORPTION, BUT NOT CLEARANCE, OF PEPTIDES IN RATS
KARLS, MS
RUSH, BD
WILKINSON, KF
VIDMAR, TJ
BURTON, PS
RUWART, MJ
[J]. PHARMACEUTICAL RESEARCH, 1991, 8 (12) : 1477 - 1481
[8] LEE VHL, 1990, ADV DRUG DELIV REV, V4, P171
[9] RENIN-ANGIOTENSIN SYSTEM - BIOCHEMISTRY AND MECHANISMS OF ACTION
PEACH, MJ
[J]. PHYSIOLOGICAL REVIEWS, 1977, 57 (02) : 313 - 370
[10] ABSOLUTE ORAL BIOAVAILABILITY OF DITEKIREN, A RENIN INHIBITOR PEPTIDE, IN CONSCIOUS RATS
RUSH, BD
WILKINSON, KF
ZHONG, WZ
CLOSSON, SK
LAKINGS, DB
RUWART, MJ
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1991, 73 (03) : 231 - 237

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