THE INTERFERENCE BY MATERNALLY-DERIVED ANTIBODY WITH ACTIVE IMMUNIZATION OF FARM-ANIMALS AGAINST FOOT-AND-MOUTH-DISEASE

被引：37

作者：

KITCHING, RP

SALT, JS

机构：

[1] Institute for Animal Health, Pirbright Laboratory, Woking, Surrey GU24 ONF, Ash Road, Pirbright

来源：

BRITISH VETERINARY JOURNAL | 1995年 / 151卷 / 04期

关键词：

FOOT-AND-MOUTH DISEASE; MATERNAL IMMUNITY; IMMUNIZATION;

D O I：

10.1016/S0007-1935(95)80127-8

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Foot-and-mouth disease (FMD) is a highly contagious disease affecting ruminants and pigs. In countries in which control of FMD relies predominantly on vaccination, young stock ingest specific anti-FMD virus antibodies in the colostrum. This maternally-derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination. However, susceptibility to infection precedes the ability to respond to vaccination in the presence of MDA. Currently available vaccines cannot overcome this inhibitory effect of MDA, and protection of young stock can only be provided by their isolation from FMD virus.

引用

页码：379 / 389

页数：11

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