REPLICATION OF MURINE CYTOMEGALOVIRUS IN MURINE Y-1 CELLS

被引：7

作者：

SHANLEY, JD ^{[1
]}

LUTWICK, LI ^{[1
]}

DONTA, ST ^{[1
]}

机构：

[1] VET ADM HOSP,MED CTR,IOWA CITY,IA 52240

来源：

JOURNAL OF MEDICAL VIROLOGY | 1979年 / 4卷 / 04期

关键词：

epithelial cells; murine cytomegalovirus; replication;

D O I：

10.1002/jmv.1890040404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine Y‐1 cells, a continuous epithelial cell line derived from an adrenal adenocarcinoma, are highly susceptible to murine cytomegalovirus (MCMV) infection. Inoculation of these cells with MCMV results in production of infectious virus and is associated with development of both cytopathic changes and the expression of viral‐specific nuclear and cytoplasmic antigens. Examination of the ultrastructure of infected Y‐1 cells reveals MCMV in various stages of replication. Cytomegalovirus replication in this hormone‐responsive epithelial cell line should provide a model system in which virus‐host cell interactions and their effects on cellular metabolism can be studied. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：261 / 268

页数：8

共 22 条

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