REGIOSELECTIVE MUCOR-MIEHEI LIPASE-CATALYZED SYNTHESIS OF PODANDS CONTAINING A 1,3-BIS(1H-PYRAZOL-1-YL)PROPANE UNIT

被引：9

作者：

FIERROS, M ^{[1
]}

CONDE, S ^{[1
]}

MARTINEZ, A ^{[1
]}

NAVARRO, P ^{[1
]}

RODRIGUEZFRANCO, MI ^{[1
]}

机构：

[1] CSIC,INST QUIM MED,E-28006 MADRID,SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 08期

关键词：

D O I：

10.1016/0040-4020(94)01106-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of podands (acyclic crown ethers) including a 1,3-bis(1H-pyrazol-1-yl)propane unit in their molecule is described. The key step of this synthesis was a regoioselective lipase-catalyzed transesterification of the dipyrazolic tetraethylester 1 with monomethylether polyethyleneglycols. The ionophoric properties of the podands 4a-d as carriers of cations were evaluated. Molecular modelling studies and quantum-chemical calculations were used in order to elucidate the superestructures of the complexes with ammonium cations.

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页码：2417 / 2426

页数：10

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