GENOMIC LOCATION OF A HUMAN CYTOMEGALOVIRUS PROTEIN WITH PROTEIN-KINASE ACTIVITY (PK68)

被引：54

作者：

SOMOGYI, T ^{[1
]}

MICHELSON, S ^{[1
]}

MASSE, MJO ^{[1
]}

机构：

[1] INST PASTEUR, UNITE VIROL MED, F-75724 PARIS 15, FRANCE

来源：

VIROLOGY | 1990年 / 174卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90075-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A major protein of Mr 68,000 with a previously described protein kinase activity (PK68), which is induced in HCMV-infected cells, is shown to be virus encoded by means of hybrid selection. The gene coding for the corresponding 4-kb mRNA was located within map units 0.510 and 0.525. This location is the same as that of pp65, a structural protein with no attributed function. The early nature of the protein was confirmed with its mRNA first appearing 3 hr after infection under cycloheximide reversal and phosphonoacetic acid blocking conditions. Another mRNA, 97 nucleotides smaller and 5′ coterminal with PK68, which codes for a Mr 52,000 protein, was also observed. © 1990.

引用

页码：276 / 285

页数：10

共 58 条

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