A COMPARATIVE-STUDY OF 4 DIFFERENT BRONCHIAL CHALLENGE TESTS

被引：11

作者：

HAUGAARD, L

IVERSEN, M

DAHL, R

机构：

[1] Department of Respiratory Diseases, University Hospital of Aarhus

来源：

ALLERGY | 1992年 / 47卷 / 02期

关键词：

ALLERGEN INHALATION; ASTHMA; BRONCHIAL CHALLENGE; EXERCISE-INDUCED ASTHMA; HISTAMINE INHALATION; ULTRASONICALLY NEBULIZED DISTILLED WATER CHALLENGE;

D O I：

10.1111/j.1398-9995.1992.tb00954.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The correlation between 4 commonly used tests for assessment of airway hyperresponsiveness was studied in 10 asthmatics by performing bronchial challenges with histamine, ultrasonically nebulised distilled water (UNDW), exercise, and a relevant allergen. All tests were performed within 4 weeks for each individual and at least 48 h apart. A significant correlation was found between histamine challenge and exercise challenge (r = -0.74). Other correlations were substantial (0.4-0.5) but did not reach statistical significance. This suggests that the challenges have different mechanisms or pathways leading to bronchoconstriction, and assessment of the pattern of individual patients' bronchial hyperresponsiveness may require application of a number of different bronchial challenge tests. For routine use histamine challenge seems the most appropriate.

引用

页码：138 / 142

页数：5

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