ACUTE-RENAL-FAILURE SECONDARY TO LEUKOCYTE-MEDIATED ACUTE GLOMERULAR INJURY

被引：2

作者：

JENNETTE, JC

FALK, RJ

机构：

[1] Departments of Pathology and Medicinef, School of Medicine, University of North Carolina, Chapel Hill, NC

来源：

RENAL FAILURE | 1992年 / 14卷 / 03期

关键词：

D O I：

10.3109/08860229209106648

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute glomerulonephritis can cause acute renal failure. Activated neutrophils and monocytes are major effectors of glomerulonephritic renal failure. Adhesion molecules, granule enzymes, reactive oxygen radicals, lipid metabolites, and cytokines of activated neutrophils and monocytes mediate glomerular capillary constriction, occlusion, and destruction. Injurious products and biologically active mediators released by activated leukocytes have profound functional effects on mesangial cells and endothelial cells, which in turn participate in the disturbance of glomerular function, for example, by altering capillary diameter and surface area. The glomerular inflammatory events result in decreased glomerular capillary ultrafiltraton coefficient and glomerular filtration rate, as well as other functional perturbations.

引用

页码：395 / 399

页数：5

共 21 条

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