PERMEABILITY FACTOR CONTAMINATING HYALURONIDASE PREPARATIONS

被引：13

作者：

HOUCK, JC

CHANG, CM

机构：

[1] Virginia Mason Research Center, Seattle, 98101, Washington

来源：

INFLAMMATION | 1979年 / 3卷 / 04期

关键词：

D O I：

10.1007/BF00913502

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Both crude and highly purified testicular hyaluronidase preparations have been shown to contain a component which increases the permeability of the microcirculation in rat skin. This permeability activity had an isoelectric point of 7.4 while hyaluronidase was 9.4. It also could be separated from hyaluronidase by acrylamide gel electrophoresis. The permeability factor was not inhibited by serum and may explain previous observations that hyaluronidase preparations decrease the ischemia and necrosis appropriate to experimental myocardial infarction in vivo. © 1979 Plenum Publishing Corporation.

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页码：447 / 451

页数：5

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