A FULL-LENGTH MURINE 2-5A SYNTHETASE CDNA TRANSFECTED IN NIH-3T3 CELLS IMPAIRS EMCV BUT NOT VSV REPLICATION

被引：101

作者：

COCCIA, EM

ROMEO, G

NISSIM, A

MARZIALI, G

ALBERTINI, R

AFFABRIS, E

BATTISTINI, A

FIORUCCI, G

ORSATTI, R

ROSSI, GB

CHEBATH, J

机构：

[1] UNIV MESSINA, IST MICROBIOL, I-98100 MESSINA, ITALY

[2] WEIZMANN INST SCI, DEPT VIROL, IL-76100 REHOVOT, ISRAEL

[3] CNR, IST TECNOL BIOMED, ROME, ITALY

[4] UNIV PARMA, IST PATOL SPECIALE MED, I-43100 PARMA, ITALY

来源：

VIROLOGY | 1990年 / 179卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90292-Y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Treatment of cells with interferons (IFNs) induces resistance to virus infection. The 2′-5′oligo A (2-5A) synthetase/RNase L is one of the pathways leading to translation inhibition induced by IFN treatment. A murine cDNA encoding the 43-kDa 2-5A synthetase was cloned and sequenced. NIH-3T3 cell clones transfected with this cDNA expressed the enzymatic activity to various extents and exhibited resistance to encephalomyocarditis virus (EMCV) but not to vesicular stomatitis virus replication. The specific resistance to EMCV can be attributed to 2-5A synthetase. © 1990.

引用

页码：228 / 233

页数：6

共 26 条

[11] MOUSE 2-5A SYNTHETASE CDNA - NUCLEOTIDE-SEQUENCE AND COMPARISON TO HUMAN 2-5A SYNTHETASE [J].