THE EFFECTIVENESS OF INTERVENTIONS ON INCUBATION OF AIDS AS MEASURED BY SECULAR INCREASES WITHIN A POPULATION

被引：20

作者：

HOOVER, DR

MUNOZ, A

HE, YH

TAYLOR, JMG

KINGSLEY, L

CHMIEL, JS

SAAH, A

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT BIOSTAT,BALTIMORE,MD 21205

[2] UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT BIOSTAT,LOS ANGELES,CA 90024

[3] UNIV PITTSBURGH,DEPT INFECT DIS & MICROBIOL,PITTSBURGH,PA 15213

[4] NORTHWESTERN UNIV,SCH MED,CTR CANC,BIOMETRY SECT,CHICAGO,IL 60611

[5] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21205

来源：

STATISTICS IN MEDICINE | 1994年 / 13卷 / 19-20期

关键词：

D O I：

10.1002/sim.4780131920

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Methods are developed to estimate and test for the impact of intervention use on a population's survival function (time to AIDS), Each participant's history is divided into J + 1 components: Omega(0) occurring before the intervention is available and Omega(1) to Omega(J) occurring later, as the intervention becomes successively more available. Distribution free truncated Kaplan-Meier models based on time since exposure fit separately to the risk sets/outcomes in Omega(0) to Omega(J) directly show the changing patterns of survival. Multivariate proportional hazards models can be used to adjust for covariates. Application of these methods indicates that availability of proven anti-AIDS interventions may have delayed time to AIDS by 8 months in an educated HIV-1 infected homosexual cohort with good access to medical care.

引用

页码：2127 / 2139

页数：13

共 35 条

[1]

ALBOUKER J, 1993, LANCET, V341, P889

[2] INCUBATION PERIOD OF AIDS IN SAN-FRANCISCO [J].

BACCHETTI, P ;

MOSS, AR .

NATURE, 1989, 338 (6212) :251-253

[3] SEASONAL AND OTHER SHORT-TERM INFLUENCES ON UNITED-STATES AIDS INCIDENCE [J].

BACCHETTI, P .

STATISTICS IN MEDICINE, 1994, 13 (19-20) :1921-1931

[4]

Breslow NE, 1987, STAT METHODS CANC RE, V1

[5]

COX DR, 1972, J R STAT SOC B, V34, P187

[6] THE SAFETY AND EFFICACY OF ZIDOVUDINE (AZT) IN THE TREATMENT OF SUBJECTS WITH MILDLY SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV) INFECTION - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

HANSEN, N ;

COLLIER, AC ;

CAREY, JT ;

PARA, MF ;

HARDY, WD ;

DOLIN, R ;

POWDERLY, WG ;

ALLAN, JD ;

WONG, B ;

MERIGAN, TC ;

MCAULIFFE, VJ ;

HYSLOP, NE ;

RHAME, FS ;

BALFOUR, HH ;

SPECTOR, SA ;

VOLBERDING, P ;

PETTINELLI, C ;

ANDERSON, J .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (10) :727-737

[7]

Fleming T. R., 1991, COUNTING PROCESSES S

[8] THE EFFECTS ON SURVIVAL OF EARLY TREATMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

GRAHAM, NMH ;

ZEGER, SL ;

PARK, LP ;

VERMUND, SH ;

DETELS, R ;

RINALDO, CR ;

PHAIR, JP .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (16) :1037-1042

[9]

GRAHAM NMH, 1991, J ACQ IMMUN DEF SYND, V4, P267

[10]

GRAHAM NMH, 1992, LANCET, V338, P727

← 1 2 3 4 →