2-AMINO-7-PHOSPHONOHEPTANOIC ACID (AP7) PRODUCES DISCRIMINATIVE STIMULI AND ANTICONFLICT EFFECTS SIMILAR TO DIAZEPAM

被引：111

作者：

BENNETT, DA ^{[1
]}

AMRICK, CL ^{[1
]}

机构：

[1] CIBA GEIGY CORP, DIV PHARMACEUT, RES DEPT, SUMMIT, NJ 07901 USA

来源：

LIFE SCIENCES | 1986年 / 39卷 / 25期

关键词：

D O I：

10.1016/0024-3205(86)90488-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The N-methyl-D-aspartate (NMDA) receptor antagonist, AP7, was evaluated in two animal test procedures known to be sensitive to the effects of diazepam. In rats trained to discriminate diazepam from vehicle, AP7 produced dose-dependent generalization to the diazepam interoceptive stimuli. This NMDA antagonist also increased the rates of conflict responding in a chronic test procedure used to identify compounds with potential anxiolytic effects. A comparison of AP7 with diazepam and two muscle relaxants (methocarbamol and baclofen) showed that excitatory amino acid antagonists (of the receptor site stimulated by NMDA) produce a muscle relaxant effect (drug discrimination) and may represent a new class of compounds for the treatment of anxiety-related disorders (conflict test).

引用

页码：2455 / 2461

页数：7

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