DIETARY-FAT AND FATTY-ACIDS MODULATE CHOLESTEROL CHOLELITHIASIS IN THE HAMSTER

被引:36
作者
COHEN, BI
MOSBACH, EH
AYYAD, N
MIKI, S
MCSHERRY, CK
机构
[1] CUNY,MT SINAI SCH MED,NEW YORK,NY 10003
[2] KYUSHU UNIV,FAC MED,DEPT SURG,FUKUOKA 812,JAPAN
关键词
D O I
10.1007/BF02536135
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We tested two hypotheses, i) whether the type and the amount of fat in the diet will affect the formation of cholesterol gallstones in the hamsters, and ii) whether palmitic acid, a major fatty acid component of butterfat, can act as a potentiator of cholesterol cholelithiasis in the hamster. Young, male golden Syrian hamsters (Sasco) were fed a semipurified diet containing casein, corn starch, cellulose and cholesterol (0.3%) to which various types and amounts of fat (butterfat, olive oil, menhaden oil, corn oil) were added. All diets contained 2% corn oil to supply essential fatty acids to the growing hamsters. No deaths or illness occurred during the experiment. Animals fed the semipurified diet plus 4% butterfat (group 1) had a gallstone incidence of 63%. Replacement of butterfat with either olive oil, corn oil or menhaden oil prevented the formation of cholesterol gallstones entirely (groups 2-4). When total butterfat was increased from 4% to 8% (group 8), the incidence of cholesterol gallstones increased to 80%. Substitution of 4% olive oil (group 5), corn oil (group 6), or menhaden oil (group 7) for the additional 4% butterfat significantly reduced gallstones to 35%, 45% and 30%, respectively. The replacement of 4% butterfat with 1.2% palmitic acid gave the highest incidence of cholesterol gallstones (95%). These results suggest that butterfat (and one of its components, palmitic acid) intensifies gallstone formation in this model whereas mono- and polyunsaturated fats act as inhibitors of cholesterol cholelithiasis. A fatty acid, possibly palmitic acid, appears to act as lithogen in our model.
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页码:526 / 532
页数:7
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共 43 条
  • [11] Dam H, 1969, World Rev Nutr Diet, V11, P199
  • [12] DONOVAN JM, 1990, HEPATOLOGY, V12, pS94
  • [13] GRUNDY SM, 1990, J LIPID RES, V31, P1149
  • [14] DIET-INDUCED TYPE-IV-LIKE HYPERLIPIDEMIA AND INCREASED BODY-WEIGHT ARE ASSOCIATED WITH CHOLESTEROL GALLSTONES IN HAMSTERS
    HAYES, KC
    KHOSLA, P
    PRONCZUK, A
    [J]. LIPIDS, 1991, 26 (09) : 729 - 735
  • [15] Health. & N.R.C.U.C.o.D.a., 1989, DIET HLTH IMPLICATIO
  • [16] BILIARY PROTEINS - UNIQUE INHIBITORS OF CHOLESTEROL CRYSTAL NUCLEATION IN HUMAN GALLBLADDER BILE
    HOLZBACH, RT
    KIBE, A
    THIEL, E
    HOWELL, JH
    MARSH, M
    HERMANN, RE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (01) : 35 - 45
  • [17] JUNGST D, 1990, GASTROENTEROLOGY, V98, pA251
  • [18] KAJIYAMA C, 1988, HIROSHIMA J MED SCI, V29, P133
  • [19] INHIBITION OF CHOLESTEROL CRYSTAL-FORMATION BY APOLIPOPROTEINS IN SUPERSATURATED MODEL BILE
    KIBE, A
    HOLZBACH, RT
    LARUSSO, NF
    MAO, SJT
    [J]. SCIENCE, 1984, 225 (4661) : 514 - 516
  • [20] LINDSEY S, 1990, P SOC EXP BIOL MED, V195, P261, DOI 10.3181/00379727-195-43145