RNA RECOGNITION BY THE HUMAN-IMMUNODEFICIENCY-VIRUS TAT-PROTEIN AND REV-PROTEIN

被引：123

作者：

GAIT, MJ

KARN, J

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 07期

关键词：

D O I：

10.1016/0968-0004(93)90176-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The human immunodeficiency virus (HIV-1) regulatory proteins, Tat and Rev, are important potential targets for the development of new drug therapies against HIV infection. Both proteins are highly specific RNA-binding proteins that recognize cis-acting regulatory elements in the viral mRNAs. These interactions are fascinating paradigms of a new principle of RNA recognition in which the protein makes contact with functional groups displayed in a distorted major groove of an RNA duplex.

引用

收藏

页码：255 / 259

页数：5

相关论文

共 39 条

[1]

HIV-1 REV REGULATION INVOLVES RECOGNITION OF NON-WATSON-CRICK BASE-PAIRS IN VIRAL-RNA [J].

BARTEL, DP ;

ZAPP, ML ;

GREEN, MR ;

SZOSTAK, JW .

CELL, 1991, 67 (03) :529-536

[2]

ARGININE-MEDIATED RNA RECOGNITION - THE ARGININE FORK [J].

CALNAN, BJ ;

TIDOR, B ;

BIANCALANA, S ;

HUDSON, D ;

FRANKEL, AD .

SCIENCE, 1991, 252 (5009) :1167-1171

[3]

HIGH-AFFINITY BINDING OF TAR RNA BY THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT PROTEIN REQUIRES BASE-PAIRS IN THE RNA STEM AND AMINO-ACID-RESIDUES FLANKING THE BASIC REGION [J].

CHURCHER, MJ ;

LAMONT, C ;

HAMY, F ;

DINGWALL, C ;

GREEN, SM ;

LOWE, AD ;

BUTLER, PJG ;

GAIT, MJ ;

KARN, J .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 230 (01) :90-110

[4]

SPECIFIC INTERACTION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS REV PROTEIN WITH A STRUCTURED REGION IN THE ENV MESSENGER-RNA [J].

COCHRANE, AW ;

CHEN, CH ;

ROSEN, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) :1198-1202

[5]

SEQUENCE-SPECIFIC INTERACTION OF TAT PROTEIN AND TAT PEPTIDES WITH THE TRANSACTIVATION-RESPONSIVE SEQUENCE ELEMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INVITRO [J].

CORDINGLEY, MG ;

LAFEMINA, RL ;

CALLAHAN, PL ;

CONDRA, JH ;

SARDANA, VV ;

GRAHAM, DJ ;

NGUYEN, TM ;

LEGROW, K ;

GOTLIB, L ;

SCHLABACH, AJ ;

COLONNO, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8985-8989

[6]

THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS [J].

CULLEN, BR ;

MALIM, MH .

TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (09) :346-350

[7]

SPECIFIC BINDING OF HIV-1 RECOMBINANT REV PROTEIN TO THE REV-RESPONSIVE ELEMENT INVITRO [J].

DALY, TJ ;

COOK, KS ;

GRAY, GS ;

MAIONE, TE ;

RUSCHE, JR .

NATURE, 1989, 342 (6251) :816-819

[8]

EXTENSIVE SEQUENCE-SPECIFIC INFORMATION THROUGHOUT THE CAR RRE, THE TARGET SEQUENCE OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REV PROTEIN [J].

DAYTON, ET ;

KONINGS, DAM ;

POWELL, DM ;

SHAPIRO, BA ;

BUTINI, L ;

MAIZEL, JV ;

DAYTON, AI .

JOURNAL OF VIROLOGY, 1992, 66 (02) :1139-1151

[9]

CONSERVED NUCLEOTIDES IN THE TAR RNA STEM OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ARE CRITICAL FOR TAT BINDING AND TRANSACTIVATION - MODEL FOR TAR RNA TERTIARY STRUCTURE [J].

DELLING, U ;

REID, LS ;

BARNETT, RW ;

MA, MYX ;

CLIMIE, S ;

SUMNERSMITH, M ;

SONENBERG, N .

JOURNAL OF VIROLOGY, 1992, 66 (05) :3018-3025

[10]

HUMAN IMMUNODEFICIENCY VIRUS-1 TAT PROTEIN BINDS TRANS-ACTIVATION-RESPONSIVE REGION (TAR) RNA INVITRO [J].

DINGWALL, C ;

ERNBERG, I ;

GAIT, MJ ;

GREEN, SM ;

HEAPHY, S ;

KARN, J ;

LOWE, AD ;

SINGH, M ;

SKINNER, MA ;

VALERIO, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6925-6929

← 1 2 3 4 →