THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS

被引：91

作者：

CULLEN, BR ^{[1
]}

MALIM, MH ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 09期

关键词：

D O I：

10.1016/0968-0004(91)90141-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic MRNA processing and transport.

引用

收藏

页码：346 / 350

页数：5

相关论文

共 32 条

[1] REV IS NECESSARY FOR TRANSLATION BUT NOT CYTOPLASMIC ACCUMULATION OF HIV-1 VIF, VPR, AND ENV/VPU-2 RNAS [J].

ARRIGO, SJ ;

CHEN, ISY .

GENES & DEVELOPMENT, 1991, 5 (05) :808-819

[2] SPLICE SITE SELECTION, RATE OF SPLICING, AND ALTERNATIVE SPLICING ON NASCENT TRANSCRIPTS [J].

BEYER, AL ;

OSHEIM, YN .

GENES & DEVELOPMENT, 1988, 2 (06) :754-765

[3] REGULATION BY HIV REV DEPENDS UPON RECOGNITION OF SPLICE SITES [J].

CHANG, DD ;

SHARP, PA .

CELL, 1989, 59 (05) :789-795

[4]

COOK KS, 1991, NUCLEIC ACIDS RES, V19, P577

[5] REGULATION OF HIV-1 GENE-EXPRESSION [J].

CULLEN, BR .

FASEB JOURNAL, 1991, 5 (10) :2361-2368

[6] SPECIFIC BINDING OF HIV-1 RECOMBINANT REV PROTEIN TO THE REV-RESPONSIVE ELEMENT INVITRO [J].

DALY, TJ ;

COOK, KS ;

GRAY, GS ;

MAIONE, TE ;

RUSCHE, JR .

NATURE, 1989, 342 (6251) :816-819

[7] THE REV GENE-PRODUCT OF THE HUMAN IMMUNODEFICIENCY VIRUS AFFECTS ENVELOPE-SPECIFIC RNA LOCALIZATION [J].

EMERMAN, M ;

VAZEUX, R ;

PEDEN, K .

CELL, 1989, 57 (07) :1155-1165

[8] HTLV-III EXPRESSION AND PRODUCTION INVOLVE COMPLEX REGULATION AT THE LEVELS OF SPLICING AND TRANSLATION OF VIRAL-RNA [J].

FEINBERG, MB ;

JARRETT, RF ;

ALDOVINI, A ;

GALLO, RC ;

WONGSTAAL, F .

CELL, 1986, 46 (06) :807-817

[9] REV PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 AFFECTS THE STABILITY AND TRANSPORT OF THE VIRAL MESSENGER-RNA [J].

FELBER, BK ;

HADZOPOULOUCLADARAS, M ;

CLADARAS, C ;

COPELAND, T ;

PAVLAKIS, GN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) :1495-1499

[10]

FRESCO LD, 1991, MOL CELL BIOL, V11, P578

← 1 2 3 4 →