THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS

被引：91

作者：

CULLEN, BR ^{[1
]}

MALIM, MH ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 09期

关键词：

D O I：

10.1016/0968-0004(91)90141-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic MRNA processing and transport.

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页码：346 / 350

页数：5

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