PREPARATION AND REACTIONS OF 2'-VINYL AND 3'-VINYL BROMIDES OF URACIL NUCLEOSIDES - VERSATILE SYNTHONS FOR ANTI-HIV AGENTS

被引：19

作者：

HARAGUCHI, K ^{[1
]}

ITOH, Y ^{[1
]}

TANAKA, H ^{[1
]}

MIYASAKA, T ^{[1
]}

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,HATANODAI 1-5-8,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)92715-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromination and successive oxidation of 1-[5-O-(t-butyldiphenylsilyl)-3-deoxy-3-phenylseleno-beta-D-xylofuranosyl]uracil yields the 2'- and 3'-vinyl bromides, which serve as synthons for 2'- or 3'-substituted 2',3'-didehydro-2',3'-dideoxyuridines via palladium-catalyzed cross-coupling or the halogen-lithium exchange reaction.

引用

页码：3391 / 3394

页数：4

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