MOTOR-ACTIVITY CORRELATES NEGATIVELY WITH FREE-RUNNING PERIOD, WHILE POSITIVELY WITH SEROTONIN CONTENTS IN SCN IN FREE-RUNNING RATS

被引：67

作者：

SHIOIRI, T ^{[1
]}

TAKAHASHI, K ^{[1
]}

YAMADA, N ^{[1
]}

TAKAHASHI, S ^{[1
]}

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV MENTAL DISORDERS RES,KODAIRA,TOKYO,JAPAN

来源：

PHYSIOLOGY & BEHAVIOR | 1991年 / 49卷 / 04期

关键词：

MOTOR ACTIVITY; RUNNING WHEEL; FREE-RUNNING PERIOD; SEROTONIN; DOPAMINE; NOREPINEPHRINE;

D O I：

10.1016/0031-9384(91)90318-I

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Free-running period of blinded rats kept in a cage with a running wheel varied markedly, while it varied little in rats kept in a cage without a running wheel. The mean free-running period of the former group is significantly shorter than that of the latter. In the former, the free-running period correlated negatively with motor activity, indicating that activity affects the free-running period. In both groups, essentially similar diurnal patterns of biogenic amines and their metabolites were observed in various discrete areas in the brain examined. However, there was a significant difference between the two groups in several areas. In the SCN, 5-HT content correlated positively with motor activity, consequently correlated negatively to the free-running period at 3 out of 4 sampling times over 24 h but no such correlation was observed in other monoamines and their metabolites examined. These facts suggest that 5-HT may be associated with modification of the free-running period.

引用

页码：779 / 786

页数：8