DETERMINATION OF EPHEDRINE COMPOUNDS IN NUTRITIONAL SUPPLEMENTS BY CYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS

被引：61

作者：

FLURER, CL

LIN, LA

SATZGER, RD

WOLNIK, KA

机构：

[1] U.S. Food and Drug Administration, National Forensic Chemistry Center, Cincinnati, OH 45202

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 669卷 / 01期

关键词：

D O I：

10.1016/0378-4347(95)00020-J

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary electrophoresis was utilized for the separation, identification, and quantitation of ten stereoisomers in the ephedrine family; Chiral discrimination was accomplished through the use of hydroxypropyl-P-cyclodextrin, and separation was enhanced at pH 2 in the presence of tetramethylammonium chloride and sodium dodecyl sulfate. Calibration plots of the ephedrines were linear over the range 4-100 mu g/ml. This method was used in the analysis of nutritional supplements that contain Ma Huang, a Chinese herbal preparation that is made from plants in the genus Ephedra.

引用

页码：133 / 139

页数：7

共 11 条

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