POLYCLONAL LYMPHOCYTE-B STIMULATION IN HUMAN MALARIA AND ITS ASSOCIATION WITH ONGOING PARASITEMIA

被引：41

作者：

BANIC, DM

VIANAMARTINS, FS

DESOUZA, JM

PEIXOTO, TD

DANIELRIBEIRO, C

机构：

[1] OSWALDO CRUZ INST,WHO,COLLABORATING CTR RES & TRAINING IMMUNOL PARASIT DIS,POB 926,BR-21045 RIO DE JANEIRO,BRAZIL

[2] FED UNIV RIO DE JANEIRO,FAC MED,INFECT DIS SERV,RIO DE JANEIRO,BRAZIL

[3] BARROS BARRETO HOSP,BELEM,PARA,BRAZIL

[4] EVANDRO CHAGAS HOSP,RIO DE JANEIRO,BRAZIL

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 44卷 / 05期

关键词：

D O I：

10.4269/ajtmh.1991.44.571

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To study the polyclonal B-lymphocyte stimulation or activation (PBA) phenomenon in human malaria, the numbers of immunoglobulin (G, A, and M)-secreting cells in the peripheral blood, serum levels of immunoglobulins, and the presence of antibodies directed against the DNA-autoantigen were evaluated in Plasmodium falciparum- and P. vivax-infected individuals. Individuals chronically exposed to the risk of infection or nonimmune subjects who contracted malaria during first visits to endemic areas were studied. Numbers of immunoglobulin-secreting cells (IgSC) were increased dependent upon ongoing parasitemia. Levels of IgG and the anti-DNA activity were also augmented in malarious individuals from the endemic area. Study of the kinetics of PBA done in treated patients showed that PBA decreased during treatment and disappeared 5-15 days after the start of chemotherapy.

引用

页码：571 / 577

页数：7