CONVENIENT COMPUTER-PROGRAM FOR FITTING ENZYMATIC RATE LAWS TO STEADY-STATE DATA

被引：64

作者：

KOHN, MC

MENTEN, LE

GARFINKEL, D

机构：

[1] Department of Computer and Information Sciences, Moore School of Electrical Engineering D/2, University of Pennsylvania, Philadelphia

来源：

COMPUTERS AND BIOMEDICAL RESEARCH | 1979年 / 12卷 / 05期

关键词：

D O I：

10.1016/0010-4809(79)90032-6

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

A computer program for the estimation of kinetic parameters in enzymatic rate laws is described. The program includes statistical tests for the reliability of the optimal parameter values and for bias error due to a poor model. A set of criteria for selecting between models is given. The program is easy to learn, convenient to use and modify, inexpensive to use, and widely applicable. The behavior of the program with the correct and an incorrect model was examined using simulated test data. The effects of experimental design and experimental error were investigated. © 1979.

引用

页码：461 / 469

页数：9