学术探索
学术期刊
新闻热点
数据分析
智能评审

OXYGEN FREE-RADICALS AND PARKINSONS-DISEASE

被引：276
作者：
ADAMS, JD
ODUNZE, IN
机构：
[1] School of Pharmacy, University of Southern California, Los Angeles, CA 90033
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 1991年 / 10卷 / 02期
关键词：
PARKINSONS DISEASE; SUPEROXIDE RADICAL ANION; DOPAMINERGIC NEURONS; SUBSTANTIA NIGRA; CAUDATE NUCLEUS; IRON; GLUTATHIONE; DEFENSE MECHANISMS;
D O I：
10.1016/0891-5849(91)90009-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The involvement of oxygen radicals in the pathogenesis of Parkinson's disease has been suggested for some time. This article reviews the evidence supporting the involvement of oxygen radicals in the disease process in the brain. This includes a discussion of iron, lipid peroxidation, peroxidase, catalase, superoxide dismutase, and glutathione levels in the brain. In addition, various theories of induction of Parkinson's disease are discussed in relation to the possible involvement of oxygen radicals. These theories include the environmental toxin theory, the dopamine turnover theory, and the cerebral blood flow theory.
引用
收藏
页码：161 / 169
页数：9
相关论文
共 91 条
  • [81] Birkmayer, Marton, Hars, Riederer, Knoll, Youdim, L-Deprenyl increases the life expectancy of patients with Parkinson's disease, MPTP: a neurotoxin producing a parkinsonian syndrome, pp. 599-606, (1986)
  • [82] Knoll, The striatal dopamine dependency of life span in male rats. Longevity study with (−)deprenyl, Mech. Ageing Devel., 46, pp. 237-262, (1988)
  • [83] Cohen, Monoamine oxidase, hydrogen peroxide, and Parkinson's disease, Adv. Neurol., 45, pp. 119-125, (1986)
  • [84] Perlmutter, New insights into the pathophysiology of Parkinson's disease: the challenge of positron emission tomography, Trends Neurol. Sci., 11, pp. 203-208, (1988)
  • [85] Kjellmer, Andine, Hagberg, Thiringer, Extracellular increase of hypoxanthine and xanthine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia, Brain Res., 478, pp. 241-247, (1989)
  • [86] Schapira, Cooper, Dexter, Jenner, Clark, Marsden, Mitochondrial complex I deficiency in Parkinson's disease, Lancet, 1, (1989)
  • [87] Kumar, Goosmann, Krause, Nayini, Estrada, Hoehner, White, Koestner, Ultrastructural and ionic studies in global ischemic dog brain, Acta Neuropathol., 73, pp. 393-399, (1987)
  • [88] Wajner, Harkness, Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues, Biochim. Biophys. Acta, 991, pp. 79-84, (1989)
  • [89] Patt, Harken, Burton, Rodell, Piermattei, Schorr, Parker, Berger, Horesh, Terada, Linas, Cheronis, Repine, Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains, J. Clin. Invest., 81, pp. 1556-1562, (1988)
  • [90] Phebus, Perry, Clemens, Fuller, Brain anoxia release striatal dopamine in rats, Life Sci., 38, pp. 2447-2453, (1986)
12345678910