SIMPLE SEQUENCES

被引：251

作者：

TAUTZ, D

SCHLOTTERER, C

机构：

[1] Zoologisches Institut der Universität München, 80333 München

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/0959-437X(94)90067-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Simple sequences (or microsatellites) are stretches of monotonous repetitions of short (1-5 bp) nucleotide motifs that are distributed across the whole genome in eukaryotes. They are probably generated by slippage during replication and their primary mutation rate seems to be controlled predominantly by the efficiency of the mismatch repair system. Although most mutations in simple sequence loci appear to be neutral, some mutations in particular stretches have been implicated as having a role in human genetic diseases.

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收藏

页码：832 / 837

页数：6

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