INHIBITION OF SECRETIN STIMULATED PANCREATIC-SECRETION BY PANCREATIC POLYPEPTIDE

被引：46

作者：

ADRIAN, TE ^{[1
]}

BESTERMAN, HS ^{[1
]}

MALLINSON, CN ^{[1
]}

GREENBERG, GR ^{[1
]}

BLOOM, SR ^{[1
]}

机构：

[1] GREENWICH DIST HOSP,GASTROINTESTINAL UNIT,LONDON,ENGLAND

来源：

GUT | 1979年 / 20卷 / 01期

关键词：

D O I：

10.1136/gut.20.1.37

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (P < 0.05) and 24% (P < 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (P < 0.0005) and 67% (P < 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.

引用

页码：37 / 40

页数：4