EXPRESSION OF ALPHA-TUBULIN AND BETA-TUBULIN GENES DURING THE ASEXUAL AND SEXUAL BLOOD STAGES OF PLASMODIUM-FALCIPARUM

被引：50

作者：

DELVES, CJ

ALANO, P

RIDLEY, RG

GOMAN, M

HOLLOWAY, SP

HYDE, JE

SCAIFE, JG

机构：

[1] UNIV EDINBURGH, DEPT MOLEC BIOL, KINGS BLDG, MAYFIELD RD, EDINBURGH EH9 3JR, MIDLOTHIAN, SCOTLAND

[2] UNIV EDINBURGH, DEPT GENET, EDINBURGH EH9 3JR, MIDLOTHIAN, SCOTLAND

[3] UNIV MANCHESTER, INST SCI & TECHNOL, DEPT BIOCHEM & APPL MOLEC BIOL, MANCHESTER M60 1QD, LANCS, ENGLAND

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 43卷 / 02期

基金：

英国惠康基金;

关键词：

Intron splicing; Plasmodium falciparum; Stage-specific transcription; Tubulin gene;

D O I：

10.1016/0166-6851(90)90151-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malaria parasites switch to sexual development after a period of vegetative growth in the host's erythrocytes. This switch, vital for parasite transmission to mosquitoes, is little understood at the genetic level. Likely candidates for developmental control are the α- and β-tubulin subunits required for microtubule assembly. We report here that the transcription of the α- and β-tubulin genes in Plasmodium falciparum show a radically different pattern of transcription in the asexual and sexual phases of parasite growth. Our studies lead to the conclusion that three transcripts of the β-tubulin gene differ by sequences in their 5′- or 3′-untranslated regions. © 1990.

引用

页码：271 / 278

页数：8

共 33 条

[11] DIFFERENTIAL EXPRESSION OF MESSENGER-RNAS FOR ALPHA-TUBULIN AND BETA-TUBULIN DURING DIFFERENTIATION OF THE PARASITIC PROTOZOAN LEISHMANIA-MEXICANA [J].