KINETIC INTERACTION OF BIOFILM CELLS OF STAPHYLOCOCCUS-AUREUS WITH CEPHALEXIN AND TOBRAMYCIN IN A CHEMOSTAT SYSTEM

被引:29
作者
ANWAR, H [1 ]
STRAP, JL [1 ]
COSTERTON, JW [1 ]
机构
[1] UNIV CALGARY,DEPT BIOL SCI,CALGARY T2N 1N4,ALBERTA,CANADA
关键词
D O I
10.1128/AAC.36.4.890
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Planktonic and young biofilm cells were completely eradicated after exposure of these cells to drug levels representing one loading and two maintenance doses of tobramycin and cephalexin. A very different picture was observed when antibiotic exposure was initiated on day 21. Complete eradication of the old biofilm cells was not observed even when the antibiotic exposure was continued for an extra 6 days. Regrowth of the organism was observed when the antibiotic exposure was terminated.
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收藏
页码:890 / 893
页数:4
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