EFFICACY AND SAFETY OF 10-DEAZAAMINOPTERIN IN THE TREATMENT OF RHEUMATOID-ARTHRITIS - A ONE-YEAR CONTINUATION, DOUBLE-BLIND-STUDY

被引：5

作者：

ALARCON, GS

CASTANEDA, O

FERRANDIZ, M

KRUMDIECK, CL

KOOPMAN, WJ

机构：

[1] UNIV ALABAMA,DEPT NUTR SCI,BIRMINGHAM,AL 35294

[2] VET ADM MED CTR,BIRMINGHAM,AL

[3] UNIV PERUANA,CAYETANO HEREDIA,DEPT MED,LIMA,PERU

来源：

ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 11期

关键词：

D O I：

10.1002/art.1780351112

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Objective. To determine the long-term safety and efficacy of 10-deazaaminopterin (10-DAM) in the treatment of rheumatoid arthritis (RA). Methods. A 1-year continuation of an initial 15-week randomized, double-blind clinical trial of 10-DAM and methotrexate (MTX). Results. 10-DAM (n = 10) and MTX (n = 8) had comparable safety and efficacy profiles. One 10-DAM-treated and 2 MTX-treated patients experienced transient side effects; 1 MTX-treated patient experienced recurrent nausea and discontinued MTX. Conclusion. 10-DAM appears to be as beneficial and as safe as MTX for the treatment of RA.

引用

页码：1318 / 1321

页数：4

共 12 条

[1]

METHOTREXATE IN RHEUMATOID-ARTHRITIS - TOXIC EFFECTS AS THE MAJOR FACTOR IN LIMITING LONG-TERM TREATMENT [J].