GENETIC-ANALYSIS OF HERPES-SIMPLEX VIRUS TYPE-1 ISOLATES FROM RECURRENT LESIONS AND CLINICAL REINFECTIONS

被引：5

作者：

ROJAS, JM

SANCHEZPALOMINO, S

SANTANA, M

LOPEZGALINDEZ, C

TABARES, E

机构：

[1] UNIV AUTONOMA MADRID,INST SALUD CARLOS 3,CTR NACL BIOL CELULAR & RETROVIRUS,MADRID,SPAIN

[2] UNIV AUTONOMA MADRID,FAC MED,DEPT MICROBIOL,MADRID,SPAIN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 06期

关键词：

D O I：

10.1093/infdis/172.6.1602

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A study of the genetic variability of herpes simplex virus (HSV) type 1 from recurrent lesions and clinical reinfections was done using restriction endonuclease analysis and the RNase A mismatch cleavage method, Comparative genetic analyses of HSV-1 recurrent isolates from 1 patient and of HSV-1 isolates from different anatomic areas (vagina and lip) from another patient showed differences only in the glycoprotein B gene but not in the thymidine kinase gene even though the viruses had the same restriction endonuclease pattern. These results suggest the RNase A mismatch cleavage method is useful for epidemiologic studies of DNA viruses.

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页码：1602 / 1605

页数：4

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