PH-RESPONSIVE LIPOSOMES WHICH CONTAIN AMPHIPHILES PREPARED BY USING LIPOPHILIC RADICAL INITIATOR

被引：80

作者：

KITANO, H

AKATSUKA, Y

ISE, N

机构：

[1] Department of Polymer Chemistry, Kyoto University, Kyoto

来源：

MACROMOLECULES | 1991年 / 24卷 / 01期

关键词：

D O I：

10.1021/ma00001a007

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A lipophilic azo radical initiator having two N,N-dioctadecylamide groups was prepared, and oligomerization of acrylic, acid was carried out by using the initiator. The amphiphiles obtained formed a stable liposome with dipalmitoylphosphatidylcholine (DPPC), and the liposome showed a pH-responsive release of fluorophore, Eosin Y, from an inner water pool of the liposome to the bulk phase. Effects of the degree of oligomerization, content of the liposome, salt concentration, and temperature on the pH sensitivity were examined. In conclusion, the amphiphiles can be used as a component of a pH-responsive device.

引用

页码：42 / 46

页数：5

共 16 条

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