LONGITUDINAL MRI IN MULTIPLE-SCLEROSIS - CORRELATION BETWEEN DISABILITY AND LESION BURDEN

被引：119

作者：

KHOURY, SJ

GUTTMANN, CRG

ORAV, EJ

HOHOL, MJ

AHN, SS

HSU, L

KIKINIS, R

MACKIN, GA

JOLESZ, FA

WEINER, HL

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT RADIOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115

来源：

NEUROLOGY | 1994年 / 44卷 / 11期

关键词：

D O I：

10.1212/WNL.44.11.2120

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or Al and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.

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页码：2120 / 2124

页数：5

相关论文

共 23 条

[1]

[Anonymous], 1990, ANN NEUROL, V27, P591

[2] SERIAL STUDY OF GADOLINIUM-DTPA MRI ENHANCEMENT IN MULTIPLE-SCLEROSIS [J].

BASTIANELLO, S ;

POZZILLI, C ;

BERNARDI, S ;

BOZZAO, L ;

FANTOZZI, LM ;

BUTTINELLI, C ;

FIESCHI, C .

NEUROLOGY, 1990, 40 (04) :591-595

[3] QUANTITATIVE MULTIPLE-SCLEROSIS PLAQUE ASSESSMENT WITH MAGNETIC-RESONANCE IMAGING - ITS CORRELATION WITH CLINICAL-PARAMETERS, EVOKED-POTENTIALS, AND INTRA-BLOOD-BRAIN BARRIER IGG SYNTHESIS [J].

BAUMHEFNER, RW ;

TOURTELLOTTE, WW ;

SYNDULKO, K ;

WALUCH, V ;

ELLISON, GW ;

MEYERS, LW ;

COHEN, SN ;

OSBORNE, M ;

SHAPSHAK, P .

ARCHIVES OF NEUROLOGY, 1990, 47 (01) :19-26

[4] THE EFFECT OF HIGH-DOSE STEROIDS ON MRI GADOLINIUM ENHANCEMENT IN ACUTE DEMYELINATING LESIONS [J].

BURNHAM, JA ;

WRIGHT, RR ;

DREISBACH, J ;

MURRAY, RS .

NEUROLOGY, 1991, 41 (09) :1349-1354

[5]

EDWARDS MK, 1986, AM J NEURORADIOL, V7, P595

[6] QUANTITATIVE BRAIN MRI LESION LOAD PREDICTS THE COURSE OF CLINICALLY ISOLATED SYNDROMES SUGGESTIVE OF MULTIPLE-SCLEROSIS [J].

FILIPPI, M ;

HORSFIELD, MA ;

MORRISSEY, SP ;

MACMANUS, DG ;

RUDGE, P ;

MCDONALD, WI ;

MILLER, DH .

NEUROLOGY, 1994, 44 (04) :635-641

[7] MAGNETIC-RESONANCE-IMAGING LESION ENLARGEMENT IN MULTIPLE-SCLEROSIS - DISEASE-RELATED ACTIVITY, CHANCE OCCURRENCE, OR MEASUREMENT ARTIFACT [J].

GOODKIN, DE ;

ROSS, JS ;

MEDENDORP, SV ;

KONESCSNI, J ;

RUDICK, RA .

ARCHIVES OF NEUROLOGY, 1992, 49 (03) :261-263

[8] MULTIPLE-SCLEROSIS - SERIAL STUDY OF GADOLINIUM-ENHANCED MR IMAGING [J].

GROSSMAN, RI ;

BRAFFMAN, BH ;

BRORSON, JR ;

GOLDBERG, HI ;

SILBERBERG, DH ;

GONZALEZSCARANO, F .

RADIOLOGY, 1988, 169 (01) :117-122

[9] MULTIPLE-SCLEROSIS - A SERIAL STUDY USING MRI IN RELAPSING PATIENTS [J].

ISAAC, C ;

LI, DKB ;

GENTON, M ;

JARDINE, C ;

GROCHOWSKI, E ;

PALMER, M ;

KASTRUKOFF, LF ;

OGER, J ;

PATY, DW .

NEUROLOGY, 1988, 38 (10) :1511-1515

[10]

KATZ D, 1990, ANN NEUROL, V28, P243