RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS

被引：2909

作者：

CAMPFIELD, LA ^{[1
]}

SMITH, FJ ^{[1
]}

GUISEZ, Y ^{[1
]}

DEVOS, R ^{[1
]}

BURN, P ^{[1
]}

机构：

[1] ROCHE RES GENT, B-9000 GHENT, BELGIUM

来源：

SCIENCE | 1995年 / 269卷 / 5223期

关键词：

D O I：

10.1126/science.7624778

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recent positional cloning of the mouse ob gene and its human homolog has provided the basis to investigate the potential role of the ob gene product in body weight regulation. A biologically active form of recombinant mouse OB protein was overexpressed and purified to near homogeneity from a bacterial expression system. Peripheral and central administration of microgram doses of OB protein reduced food intake and body weight of ob/ob and diet-induced obese mice but not in db/db obese mice. The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance.

引用

页码：546 / 549

页数：4