METABOLIC ACTIVATION OF BENZO(A)PYRENE AND 9-HYDROXYBENZO(A)PYRENE BY LIVER MICROSOMAL FRACTIONS

被引：28

作者：

LUBET, RA

CAPDEVILA, J

PROUGH, RA

机构：

[1] Department of Biochemistry, University of Texas Health Science Center, Dallas, Texas, 75235

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 03期

关键词：

D O I：

10.1002/ijc.2910230313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A rat liver microsome‐mediated bacterial mutagenicity test showed 9‐hydroxybenzo (a) pyrene to be significantly more effective as a pre‐mutagen than benzo (a) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late exogenous DNA demonstrated that 9‐hydroxybenzo (a) pyrene was almost six times more effective than benzo (a) pyrene itself. Addition of trichloropropene‐2,3‐oxide to the reaction mixture enhanced the mutagenicity and DNA alkylation by benzo (a) pyrene but had little or no effect on the 9‐hydroxybenzo (a) pyrenemediated mutagenicity and alkylation. On the other hand, 7,8‐benzoflavone inhibited the microsome‐mediated mutagenicity and DNA alkylating activity of both hydrocarbons. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：353 / 357

页数：5

共 24 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].