AGING AND ELICITING AGENTS - EFFECT ON MURINE PERITONEAL MACROPHAGE MONOKINE BIOACTIVITY

被引：23

作者：

CHEN, YF

BRADLEY, SF

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GERIATR MED,ANN ARBOR,MI 48105

[2] UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV INFECT DIS,ANN ARBOR,MI 48105

[3] DEPT VET AFFAIRS MED CTR,ANN ARBOR,MI 48105

来源：

EXPERIMENTAL GERONTOLOGY | 1993年 / 28卷 / 02期

关键词：

INTERLEUKIN-1; INTERLEUKIN-6; TUMOR NECROSIS FACTOR; COMPLETE FREUND ADJUVANT; THIOGLYCOLATE; AGE;

D O I：

10.1016/0531-5565(93)90004-W

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Decreased responsiveness of the aged to infection may be associated with a decline in monokine production. Prior studies in macrophages have used different eliciting agents, and results have varied. We assessed the effect of age on interleukin-1 (IL-1), tumor necrosis factor (TNF), and interleukin-6 (IL-6) in unelicited, thioglycollate (TG)-elicited, and complete Freund's adjuvant (CFA)-elicited peritoneal macrophages. Resident macrophages or CFA-elicited macrophages from middle aged or aged mice produced significantly less monokine bioactivity than resident or CFA-elicited macrophages from young mice. Monokine bioactivity from TG-elicited macrophages from aged and middle aged mice was significantly increased when compared with macrophages of young mice. Eliciting agents may alter macrophage populations and interactions with other cells leading to changes in monokine bioactivity with aging.

引用

页码：145 / 159

页数：15