LOSS OF HETEROZYGOSITY OCCURS AT THE D11S29 LOCUS ON CHROMOSOME 11Q23 IN INVASIVE CERVICAL-CARCINOMA

被引:54
作者
BETHWAITE, PB
KORETH, J
HERRINGTON, CS
MCGEE, JOD
机构
[1] Nuffield Department of Pathology and Bacteriology, University of Oxford, John Radcliffe Hospital, Oxford
关键词
CERVIX NEOPLASMS; HUMAN CHROMOSOME 11; LOSS OF HETEROZYGOSITY; TUMOR-SUPPRESSOR GENES; MICROSATELLITES; POLYMERASE CHAIN REACTION;
D O I
10.1038/bjc.1995.157
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Allelotypic detection of loss of heterozygosity (LOH) has been used to identify putative tumour-suppressor genes. Loci on human chromosome 11q23 are frequently altered in malignant disease, and LOH has been reported at an anonymous D11S29 locus at 11q23 in a proportion of breast and ovarian cancers and malignant melanomas. Previous studies have reported a high frequency of LOH in cervical carcinoma mapping to 11q23. Using polymerase chain reaction techniques employing probes for a recently described polymorphic dinucleotide microsatellite within this locus, we have searched for LOH in 69 cases of invasive cervical carcinoma. Genomic material was microdissected from sections cut from archival paraffin-embedded material, using the patients' constitutional genotype as a control Sixty-two (90%) of the cases were informative, and LOH occurred in 25/62 (40%) of tumours. Loss of an arm or single chromosome 11 is a well-recognised event in cervical carcinoma, and by employing other microsatellite polymorphisms mapping to 11q13 and 11p11-p12 we excluded those cases with widespread allelic loss. By doing so, LOH at D11S29 was found in 16/53 (30%) of tumours. The findings suggest a putative tumour-suppressor gene on 11q involved in cervical carcinogenesis.
引用
收藏
页码:814 / 818
页数:5
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