CONFORMATIONAL PREFERENCES AND PROTONATION SEQUENCE OF MYOINOSITOL HEXAPHOSPHATE IN AQUEOUS-SOLUTION - POTENTIOMETRIC AND MULTINUCLEAR MAGNETIC-RESONANCE STUDIES

被引:39
作者
BRIGANDO, C [1 ]
MOSSOYAN, JC [1 ]
FAVIER, F [1 ]
BENLIAN, D [1 ]
机构
[1] UNIV PROVENCE,CHIM COORDINAT LAB,D22,F-13397 MARSEILLE 20,FRANCE
来源
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1995年 / 04期
关键词
D O I
10.1039/dt9950000575
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Potentiometric methods and multinuclear NMR spectroscopy have been used to determine the protonation sequence and conformational preferences of myo-inositol (cyclohexane-1,2,3,4,5,6-hexol) hexaphosphate over the range pH 0-12. The H-1, P-31 and C-13 resonances have been assigned from both homo- and hetero-nuclear coupling constants obtained by one- and two-dimensional NMR spectroscopy. The phosphate exists in aqueous solution in either of two conformations, axial and equatorial, as a result of intramolecular hydrogen-bond formation between phosphate groups which leads to stabilization of the equatorial form up to pH 10 and of the axial at pH > 10. Analysis of lanthanide-induced shift data shows unambiguously that the last protonation occurs on the P2 phosphate group in strongly acidic media.
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收藏
页码:575 / 578
页数:4
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