THE BASE EXCISION-REPAIR PATHWAY

被引：445

作者：

SEEBERG, E ^{[1
]}

EIDE, L ^{[1
]}

BJORAS, M ^{[1
]}

机构：

[1] UNIV OSLO,NATL HOSP,INST MED MICROBIOL,DEPT BIOL MOLEC,N-0027 OSLO,NORWAY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(00)89086-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

引用

页码：391 / 397

页数：7

共 50 条

[1] CLONING AND EXPRESSION IN ESCHERICHIA-COLI OF A GENE FOR AN ALKYLBASE DNA GLYCOSYLASE FROM SACCHAROMYCES-CEREVISIAE - A HOMOLOG TO THE BACTERIAL ALKA GENE [J].

BERDAL, KG ;

BJORAS, M ;

BJELLAND, S ;

SEEBERG, E .

EMBO JOURNAL, 1990, 9 (13) :4563-4568

[2] REPAIR OF 8-HYDROXYGUANINE IN DNA BY MAMMALIAN N-METHYLPURINE-DNA GLYCOSYLASE [J].

BESSHO, T ;

ROY, R ;

YAMAMOTO, K ;

KASAI, H ;

NISHIMURA, S ;

TANO, K ;

MITRA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :8901-8904

[3]

BJELLAND S, 1994, J BIOL CHEM, V269, P30489

[4]

BJELLAND S, IN PRESS BIOCHEMISTR

[5] PURIFICATION AND PROPERTIES OF THE ALKYLATION REPAIR DNA GLYCOSYLASE ENCODED BY THE MAG GENE FROM SACCHAROMYCES-CEREVISIAE [J].

BJORAS, M ;

KLUNGLAND, A ;

JOHANSEN, RF ;

SEEBERG, E .

BIOCHEMISTRY, 1995, 34 (14) :4577-4582

[6] DNA-POLYMERASE-DELTA IS REQUIRED FOR BASE EXCISION-REPAIR OF DNA METHYLATION DAMAGE IN SACCHAROMYCES CERVISIAE [J].

BLANK, A ;

KIM, B ;

LOEB, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :9047-9051

[7] SUBSTRATE-SPECIFICITY OF THE ESCHERICHIA-COLI FPG PROTEIN (FORMAMIDOPYRIMIDINE DNA GLYCOSYLASE) - EXCISION OF PURINE LESIONS IN DNA PRODUCED BY IONIZING-RADIATION OR PHOTOSENSITIZATION [J].

BOITEUX, S ;

GAJEWSKI, E ;

LAVAL, J ;

DIZDAROGLU, M .

BIOCHEMISTRY, 1992, 31 (01) :106-110

[8] A MAMMALIAN-CELL LINE DEFICIENT IN ACTIVITY OF THE DNA-REPAIR ENZYME 5-HYDROXYMETHYLURACIL-DNA GLYCOSYLASE IS RESISTANT TO THE TOXIC EFFECTS OF THE THYMIDINE ANALOG 5-HYDROXYMETHYL-2'-DEOXYURIDINE [J].

BOORSTEIN, RJ ;

CHIU, LN ;

TEEBOR, GW .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) :5536-5540

[9] AN INTERACTION BETWEEN THE MAMMALIAN DNA-REPAIR PROTEIN XRCC1 AND DNA LIGASE-III [J].

CALDECOTT, KW ;

MCKEOWN, CK ;

TUCKER, JD ;

LJUNGQUIST, S ;

THOMPSON, LH .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (01) :68-76

[10] HU PROTEIN OF ESCHERICHIA-COLI BINDS SPECIFICALLY TO DNA THAT CONTAINS SINGLE-STRAND BREAKS OR GAPS [J].

CASTAING, B ;

ZELWER, C ;

LAVAL, J ;

BOITEUX, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (17) :10291-10296

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