THE BASE EXCISION-REPAIR PATHWAY

被引：445

作者：

SEEBERG, E ^{[1
]}

EIDE, L ^{[1
]}

BJORAS, M ^{[1
]}

机构：

[1] UNIV OSLO,NATL HOSP,INST MED MICROBIOL,DEPT BIOL MOLEC,N-0027 OSLO,NORWAY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(00)89086-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

引用

页码：391 / 397

页数：7

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