SYNTHETIC STUDIES ON FULLY SUBSTITUTED GAMMA-PYRONE-CONTAINING NATURAL-PRODUCTS - THE FIRST TOTAL SYNTHESIS OF ONCHITRIOL-II

被引：16

作者：

ARIMOTO, H ^{[1
]}

NISHIYAMA, S ^{[1
]}

YAMAMURA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 51期

关键词：

D O I：

10.1016/0040-4039(94)88516-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of onchitriol II, a cytotoxic metabolite of mollusc Onchidium sp., is described. It employs mild cyclization method [DMSO - (COCl)(2) or Ph(3)P - CCl4] of triketides bearing optically active functional groups to the corresponding gamma-pyrones as a key step. Additional synthesis of some diastereoisomers provided a possibility to revise the structure of closely related onchitriol I.

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页码：9581 / 9584

页数：4

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