BIOLOGIC EFFECTS OF AN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN ON INTERLEUKIN-1-STIMULATED CARTILAGE EROSION AND CHONDROCYTE RESPONSIVENESS

被引：103

作者：

SMITH, RJ

CHIN, JE

SAM, LM

JUSTEN, JM

机构：

[1] Department of Hypersensitivity Diseases Research, Upjohn Company, Kalamazoo, Michigan

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 01期

关键词：

D O I：

10.1002/art.1780340112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recombinant human interleukin-1-alpha (IL-1-alpha) and recombinant human IL-1-beta stimulate matrix proteoglycan degradation and inhibit glycosaminoglycan synthesis in bovine nasal cartilage explants. A 17-kd human recombinant IL-1 receptor antagonist protein (IRAP) caused a concentration-dependent (0.2-200 ng/ml) suppression of the effects of IL-1-alpha and IL-1-beta in cartilage organ cultures. IRAP inhibited the binding of radiolabeled IL-1-alpha to rabbit articular chondrocytes. Matrix metalloproteinase (collagenase, gelatinase, and stromelysin) and prostanoid production by IL-1-activated rabbit articular chondrocytes was also suppressed by IRAP. These results could have potential significance in the development of a new antiarthritis therapy based on an IRAP.

引用

页码：78 / 83

页数：6

共 17 条

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