STIMULATORY EFFECTS OF ISLET AMYLOID POLYPEPTIDE (AMYLIN) ON EXOCRINE PANCREAS AND GASTRIN-RELEASE IN CONSCIOUS RATS

被引：19

作者：

FUNAKOSHI, A

MIYASAKA, K

KITANI, K

NAKAMURA, J

FUNAKOSHI, S

FUKUDA, H

FUJII, N

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT CLIN PHYSIOL,TOKYO 173,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,KYOTO 606,JAPAN

来源：

REGULATORY PEPTIDES | 1992年 / 38卷 / 02期

关键词：

AMYLIN; PANCREATIC SECRETION;

D O I：

10.1016/0167-0115(92)90052-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A rat islet amyloid polypeptide (amylin), 37-residue peptide amide was synthesized by the Fmoc-based solid phase method and the biological activity of synthetic rat amylin on exocrine pancreas was evaluated for the first time in conscious rat. Amylin (1,10 nmol/kg/h) stimulated pancreatic exocrine secretion and plasma gastrin concentration. CR-1409, a CCK receptor antagonist, did not change amylin-stimulated pancreatic secretion. However, omeprazole (proton pump inhibitor) and atropine inhibited amylin-stimulated pancreatic secretion. This study suggests that amylin may play a role in biological action in the exocrine pancreas possibly mediated by gastric acid hypersecretion.

引用

页码：135 / 143

页数：9

共 19 条

[1] PURIFICATION AND CHARACTERIZATION OF A PEPTIDE FROM AMYLOID-RICH PANCREASES OF TYPE-2 DIABETIC-PATIENTS [J].