THE CHEMISTRY OF 2',3'-SECONUCLEOSIDES .4. SYNTHESIS AND REACTIONS OF 3'-AZIDO-2',3'-DIDEOXY-2',3'-SECOTHYMIDINE AND RELATED ANALOGS

被引：26

作者：

KUMAR, A ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

TETRAHEDRON | 1990年 / 46卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(01)85449-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of 2,3-seconucleoside analogues related to nucleosides previously shown to possess anti-HIV activity is described. Using strategies to distinguish between the three primary hydroxyl groups of a 2,3-seconucleoside, 3-azido-2,3-dideoxy-2,3-secothymidine and 2,3-dideoxy-2,3- secothymidine have been prepared. These compounds, several of the intermediates in their synthesis, as well as O22-anhydro-3-azido-3-deoxy-2,3-secothymidine and several 2,3-secouridine analogues have been tested for their ability to prevent infection of cells by HIV. None showed any significant toxicity or antiviral activity. © 1990.

引用

页码：3101 / 3110

页数：10

共 15 条

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