EXPERIMENTAL ACUTE TRAUMATIC INJURY OF THE ADULT-RAT SPINAL-CORD BY A SUBDURAL INFLATABLE BALLOON - METHODOLOGY, BEHAVIORAL-ANALYSIS, AND HISTOPATHOLOGY

被引：64

作者：

MARTIN, D

SCHOENEN, J

DELREE, P

GILSON, V

ROGISTER, B

LEPRINCE, P

STEVENAERT, A

MOONEN, G

机构：

[1] STATE UNIV LIEGE,DEPT NEUROSURG,B-4000 LIEGE,BELGIUM

[2] STATE UNIV LIEGE,DEPT PHYSIOL & PATHOPHYSIOL,B-4000 LIEGE,BELGIUM

[3] STATE UNIV LIEGE,DEPT NEUROL,B-4000 LIEGE,BELGIUM

[4] STATE UNIV LIEGE,DEPT NEUROPATHOL,B-4000 LIEGE,BELGIUM

[5] STATE UNIV LIEGE,DEPT RADIOL,B-4000 LIEGE,BELGIUM

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1992年 / 32卷 / 04期

关键词：

NEUROPATHOLOGY OF CORD INJURY; MOTOR ASSESSMENT; SPINAL CORD INJURY; SPINAL CORD INJURY MODEL;

D O I：

10.1002/jnr.490320409

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit.

引用

页码：539 / 550

页数：12